Introduction to Biological and Small Molecule Drug Research and Development: Chapter 8. Discovery and development of the anticancer agent gefitinib, an ... growth factor receptor tyrosine kinase Book PDF, ePub eBook

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Book Descriptions:
The epidermal growth factor receptor (EGFR) tyrosine kinase is a target for cancer chemotherapy. This chapter describes the discovery of small-molecule inhibitors of the kinase, their characterization and the medicinal chemistry programme that resulted in the identification of gefitinib. The development and studies undertaken to progress the drug in the clinic are presented together with a brief summary of other inhibitors of the EGFR kinase and their properties.

Introduction to Biological and Small Molecule Drug Research and Development: Chapter 8. Discovery and development of the anticancer agent gefitinib, an ... growth factor receptor tyrosine kinase by Andy Barker, David Anrews

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