Diabetes: Chapter 18. The Protective Role of Taurine in Cardiac Oxidative Stress under Diabetic Conditions Book PDF, ePub eBook

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Book Descriptions:
Diabetes mellitus (DM) is the outcome of an absolute or relative deficiency of insulin characterized by persistent hyperglycemia and disturbances in carbohydrate, fat, and protein metabolism. DM is one of the leading causes of morbidity and mortality worldwide, predominantly from vascular complications such as atherothrombosis in the coronary vessels. Hyperglycemia-induced oxidative stress plays an important role in the development and progression of diabetes and its associated complications in cardiovascular disease, as is evident from increased levels of oxidized DNA, proteins and lipids. Therefore, treatment with antioxidants in diabetic patients may benefit cardiac dysfunction by attenuation of myocardial oxidative stress. Taurine is found in large concentrations in all mammalian tissues, particularly in heart, and it possesses both hypoglycemic and antioxidant properties. This chapter summarizes the mechanism of the induction of oxidative stress in diabetic heart, its effect on cardiac dysfunction and the prophylactic role of taurine against diabetic-cardiac oxidative stress.

Diabetes: Chapter 18. The Protective Role of Taurine in Cardiac Oxidative Stress under Diabetic Conditions by Joydeep Das, Parames C. Sil

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